CORRELATION OF DENGUE VIRUS SEROTYPE AND DVI SEVERITY IN ADULT PATIENTS

Correlation of Serotype-Specific Dengue Virus Infection with Clinical Manifestations

BACKGROUND Disease caused by the dengue virus (DENV) is a significant cause of morbidity throughout the world. Although prior research has focused on the association of specific DENV serotypes (DENV-1, DENV-2, DENV-3, and DENV-4) with the development of severe outcomes such as dengue hemorrhagic fever and dengue shock syndrome, relatively little work has correlated other clinical manifestations...

Dengue viremia titer, antibody response pattern, and virus serotype correlate with disease severity.

Viremia titers in serial plasma samples from 168 children with acute dengue virus infection who were enrolled in a prospective study at 2 hospitals in Thailand were examined to determine the role of virus load in the pathogenesis of dengue hemorrhagic fever (DHF). The infecting virus serotype was identified for 165 patients (DEN-1, 46 patients; DEN-2, 47 patients; DEN-3, 47 patients, DEN-4, 25 ...

Dengue Virus Serotype 4, Northeastern Peru, 2008

In 2008, dengue virus serotype 4 (DENV-4) emerged in northeastern Peru, causing a large outbreak and displacing DENV-3, which had predominated for the previous 6 years. Phylogenetic analysis of 2008 and 2009 isolates support their inclusion into DENV-4 genotype II, forming a lineage distinct from strains that had previously circulated in the region.

Dengue Virus Serotype 3, Karachi, Pakistan

Dengue Virus Serotype 4, Roraima State, Brazil

bred outdoors in malaria-endemic areas is not uncommon. However, with the exception of P. knowlesi, it is my understanding that malarial organisms found in cynomolgus monkeys do not pose a major zoonotic concern (although this can always change). Furthermore, it is my understanding that P. vivax does not infect macaques, including cynomolgus monkeys. Other malarial parasites of cynomolgus monke...